Photonic antennas for ultra-sensitive biomolecular detection
Ultra-sensitive bio-sensing and bio-nanodevicesProject description
Nanophotonics offer new opportunities to further improve single molecule optical detection beyond the diffraction limit. We exploit novel concepts of photonic antennas to generate new bionanophotonic tools for ultrasensitive detection of individual biomolecules in the micro-molar range. The major goal is to engineer photonic antenna devices to concentrate the light into nanometer-scale illumination volumes and simultaneously enhance the molecular emission. Single molecule spectroscopy techniques such as fluorescence correlation spectroscopy (FCS) and fluorescence resonance energy transfer (FRET) can greatly benefit from photonic nanoantennas to enter a new dimension of higher sensitivities at molecular concentrations reaching physiological conditions.
ICFO groups associated with the project
ICFO publications associated with the project
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Roadmap on biosensing and photonics with advanced nano-optical methods
E.D. Fabrizio, S. Schlücker, J. Wenger, R. Regmi, H. Rigneault, G. Calafiore, M. West, S. Cabrini, M. Fleischer, N.F. van Hulst, M.F. Garcia-Parajo, A. Pucci, D. Cojoc, C.A.E. Hauser, and M. Ni,Journal of Optics, vol. 18, pp. 063003, 2016.
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Matching Nanoantenna Field Confinement to FRET Distances Enhances Förster Energy Transfer Rates
P. Ghenuche, M. Mivelle, J. de Torres, S.B. Moparthi, H. Rigneault, N.F. Van Hulst, M.F. García-Parajó, and J. Wenger,Nano Letters, vol. 15, pp. 6193-6201, 2015.
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Strong Modification of Magnetic Dipole Emission through Diabolo Nanoantennas
M. Mivelle, T. Grosjean, G.W. Burr, U.C. Fischer, and M.F. Garcia-Parajo,ACS Photonics, vol. 2, pp. 1071-1076, 2015.
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Nanophotonic approaches for nanoscale imaging and single‐molecule detection at ultrahigh concentrations
M. Mivelle, T.S. Van Zanten, C. Manzo, and M.F. Garcia‐Parajo,Microscopy Research and Technique, vol. 77, pp. 537-545, 2014.
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A plasmonic ‘antenna-in-box’ platform for enhanced single-molecule analysis at micromolar concentrations
D. Punj, M. Mivelle, S.B. Moparthi, T.S. van Zanten, H. Rigneault, N.F. van Hulst, M.F. García-Parajó, and J. Wenger,Nature Nanotechnology, vol. 8, pp. 512-516, 2013.
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Ultrabright Bowtie Nanoaperture Antenna Probes Studied by Single Molecule Fluorescence
M. Mivelle, T.S. van Zanten, L. Neumann, N.F. van Hulst, and M.F. Garcia-Parajo,Nano Letters, vol. 12, pp. 5972-5978, 2012.
External collaborations
Dr. Jerome Wenger (Institute Fresnel, Marseille, France), Prof. Juergen Brugger (Microsystems Lab, EPFL, Lausanne, Switzerland), Dr. Mathieu Mivelle (ESPCI, Paris, France)
Funding
FP7-ICT-2011-7 – NANO-VISTA, ERC – European Research Council, Advanced Grant ERC247330 – NanoAntenna
