Development of quantitative, high spatiotemporal resolution imaging methods

Development of nano-tools for quantitative bio-imaging

Project description

Super-resolution microscopy has revolutionized light microscopy, pushing the spatial resolution well below the diffraction limit. The impact of super-resolution methods have already been recognized by the Nobel Prize in Chemistry in 2014. Important challenges remain in pushing the application of these methods in biology. One of these limitations is the ability to extract quantitative information from the images, which is confounded by fluorophore photophysics. In addition, the temporal resolution is also limited by fluorophore photostability and photoswitching characteristics. We are developing methods to circumvent these limitations and extend the spatiotemporal resolution and quantitative power of super-resolution microscopy.

ICFO publications associated with the project

External collaborations

Funding

Present ERC-MOTORS (ERC-Starting Grant), FP-7- HEALTH.2010.2.1.2.2 (Systems Microscopy Network of Excellence), Future and Emerging Technologies, FET-Open, CellViewer

Past Spanish Ministry of Education, Plan Nacional, Marie Curie International Re-Integration Grant, ICFO-Startup Package

Development of quantitative, high spatiotemporal resolution imaging methods